BSc: University of British Columbia (Zoology)
MSc: University of Guelph (Zoology – physiology)
PhD: University of Guelph (Zoology – physiology/nutrition/toxicology)
Post-doctoral fellowship: University of British Columbia (Zoology – biochemistry/physiology)
Post-doctoral fellowship: University of British Columbia (Anatomy – toxicology/physiology)
Research Methods and Statistics
Horseback riding (Hunter/jumper)
My research interests are concerned with the effects of alcohol on calcium and bone metabolism. Alcohol consumption alters calcium homeostasis and has deleterious effects on bone, and I have been particularly interested in the relationship between these two effects. Specifically, my recent research has focused on the effects of drinking during pregnancy on maternal/fetal calcium homeostasis and bone growth and development. Despite warnings to the contrary, drinking during pregnancy is widespread and the incidence of Fetal Alcohol Spectrum Disorder (FASD) is estimated at close to 1% of live births. Although much is known regarding the challenges facing individuals with FASD through childhood and early adulthood, little is known about the effects of prenatal alcohol exposure on susceptibility to the chronic diseases associated with middle to late adulthood. Alcohol-induced deficits in bone growth or bone mass may have significant implications for long-term bone health and increase the risk of developing osteoporosis in later life. Understanding the factors that have a negative impact on bone loss and the attainment of peak bone mass is vital to decreasing the risk of serious health problems from osteoporosis.
Member of the Research Society on Alcoholism
Member of the Fetal Alcohol Canadian Expertise group
Member of the Canadian Society for Nutritional Sciences
Reviewer for the Ontario Women’s Health Council/ CIHR Institute of Gender and Health Mid-career Awards
Reviewer for scientific journals:
- Pediatric Research
- Molecular and Cellular Biochemistry
- Experimental Biology and Medicine
- Alcohol and Alcoholism
- Archives of Oral Biology
- Neurotoxicology and Teratology
- Alcoholism: Clinical and Experimental Research
- Comparative Biochemistry and Physiology
Reviewer for textbooks:
- Canadian versions of introductory nutrition text
- Nutrition: Concepts and Controversies
- Biochemical and Physiological Aspects of Human Nutrition
- Advanced Nutrition: Macronutrients
Toward Exercise Intervention for Children with FASD: a Strength-based Approach. C. Bertram, A. Pritchard-Orr, K. Keiver and S. Clarren. Awarded by the Victoria Foundation. 2007 – 2010.
Snow, M.E. and K. Keiver. 2007. Prenatal alcohol exposure disrupts the histological stages of fetal bone development. Bone 41: 181-187.
Duggal, S., M.E. Simpson and K. Keiver. 2007. Effect of chronic ethanol consumption on the response of parathyroid hormone to hypocalcemia in the pregnant rat. Alcohol Clin Exp Res 31:104-112.
Keiver, K., M.E. Simpson and S. Duggal. 2005. Ethanol administration results in a prolonged decrease in blood ionized calcium levels in the rat . Alcohol 37: 173-178.
Sran, M.M., Khan, K.M., Keiver, K., Chew, J., McKay, H.A. and T.R. Oxland. 2005.Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD, and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume. European Spine Journal 14: 971-976.
Simpson, M.E., S. Duggal and K. Keiver. 2005. Prenatal ethanol exposure has differential effects on fetal growth and skeletal ossification. Bone 36: 521-532.
Keiver, K. and J. Weinberg. 2004. Effect of duration of alcohol consumption on calcium metabolism and bone in the fetal rat. Alcohol Clin. Exp. Res. 28: 456-467.
Keiver, K. 2004. Ethanol interferes with the measurement of extracellular ionized calcium. Alcohol Clin. Exp. Res. 28: 153-159.
Keiver, K. and J. Weinberg. 2003. Effect of duration of alcohol consumption on calcium and bone metabolism during pregnancy in the rat. Alcohol Clin. Exp. Res. 27: 1507-1519.
Keiver, K., L. Ellis, A. Anzarut and J. Weinberg. 1997. The effect of prenatal ethanol exposure on fetal calcium metabolism. Alcohol Clin. Exp. Res. 21: 1612-1618.
Keiver, K.M., L. Herbert and J. Weinberg. 1996.The effect of maternal ethanol consumption on maternal and fetal calcium metabolism. Alcohol Clin. Exp. Res. 20: 1305-1312.
Keiver, K.M., J. Weinberg and P.W. Hochachka. 1992. Roles of catecholamines and corticosterone during anoxia and recovery at 5°C in turtles. Am. J. Physiol. 263: R770-R775.
Keiver, K.M., J. Weinberg and P.W. Hochachka. 1992. The effect of anoxic submergence and recovery on circulating levels of catecholamines and corticosterone in the turtle, Chrysemys picta. Gen. Comp. Endocrinol. 85: 308-315.
Keiver, K.M. and P.W. Hochachka. 1991. Catecholamine stimulation of hepatic glycogenolysis during anoxia in the turtle, Chrysemys picta. Am. J. Physiol. 261: R1341-R1345.
Keiver, K.M., H.H. Draper and K. Ronald. 1988. Vitamin D metabolism in the hooded seal (Cystophora cristata). J. Nutr. 118: 332-341.
Keiver, K.M., K. Ronald and H.H. Draper. 1988. Plasma levels of vitamin D and some metabolites in marine mammals. Can. J. Zool. 66: 1297-1300.
Keiver, K.M., M. Chandler, R. Frank and K. Ronald. 1987. Plasma and blood volumes of the hooded seal (Cystophora cristata). Can. J. Zool. 65: 1866-1867.
Ronald, K., K.M. Keiver, F.W.H. Beamish and R. Frank. 1984. Energy requirements for maintenance and faecal and urinary losses of the grey seal (Halichoerus grypus). Can. J. Zool. 62: 1101-1105.
Keiver, K.M., H.H. Draper, M. Hadley and K. Ronald. 1984. Calcium and phosphorus balance in juvenile harp seals (Phoca groenlandica). Can. J. Zool. 62: 777-782.
Keiver, K.M., K. Ronald and F.W.H. Beamish. 1984. Metabolizable energy requirements for maintenance and faecal and urinary losses of juvenile harp seals (Phoca groenlandica). Can. J. Zool. 62: 769-776.
Work in preparation:
Keiver, K., S. Duggal and M.E. Simpson Alcohol compromises fetal calcium homeostasis during acute maternal hypocalcemia. To be submitted to Alcohol.
Keiver, K. and J. Weinberg. Chronic ethanol intake alters calcium homeostasis in the non-pregnant rat. To be submitted to Alcohol.
Keiver, K., and M.E. Simpson. Time course of ethanol’s effects on calcium regulation during pregnancy in the rat. To be submitted to Alcoholism: Clinical and Experimental Research.